Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

TitleUnraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
Publication TypeJournal Article
Year of Publication2019
AuthorsYee, SWah, Stecula, A, Chien, H-C, Zou, L, Feofanova, EV, van Borselen, M, Cheung, KWun Kathy, Yousri, NA, Suhre, K, Kinchen, JM, Boerwinkle, E, Irannejad, R, Yu, B, Giacomini, KM
JournalPLoS Genet
Volume15
Issue9
Paginatione1008208
Date Published2019 Sep
ISSN1553-7404
KeywordsAndrosterone, Animals, Biological Transport, Genome-Wide Association Study, HEK293 Cells, Humans, Metabolomics, Models, Molecular, Organic Cation Transport Proteins, Phylogeny, Polymorphism, Single Nucleotide, Steroids, Symporters
Abstract

Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value

DOI10.1371/journal.pgen.1008208
Alternate JournalPLoS Genet
PubMed ID31553721
PubMed Central IDPMC6760779
Grant ListRC2 HL102419 / HL / NHLBI NIH HHS / United States
R01 DK108722 / DK / NIDDK NIH HHS / United States
HHSN268201700004C / HB / NHLBI NIH HHS / United States
R00 HL122508 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R01 GM117163 / GM / NIGMS NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700002C / HB / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
UM1 HG008898 / HG / NHGRI NIH HHS / United States

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