Drosophila melanogaster Genome Project

Image source: TheAlphaWolf (Own work) [GFDL or CC-BY-3.0], via Wikimedia Commons

The Arthropod Sequencing projects at the BCM-HGSC have all been completed and are presented on this website as historical data for informational purposes.

About the project

In a collaborative effort with the Berkeley Drosophila Genome Project (BDGP) and Celera Genomics, we have mapped and sequenced the euchromatic portion of the Drosophila melanogaster genome. Release of the drosophila sequence was in 2002 (link). The Drosophila Genome Project was funded by the National Human Genome Research Institute, National Cancer Institute, and Howard Hughes Medical Institute.

Genomic Resources

Access to the Data

BCM-HGSC data

Fingerprint assemblies are available as gif files and as raw data on the BCM-HGSC FTP site. STS content maps are available for 3L and X.
BCM-HGSC FTP site help
BCM-HGSC conditions of use
Flybase BLAST—Searches all Drosophila reads and provides links to the individual matched sequences through the NCBI.
Flybase Genome Overview
Clones are available from BACPAC resources.
International Genome Consortium Database
Sequences in GenBank

Additional Resources

Learn more about Drosophila melanogaster

Related Publications

Wiegmann BM, Richards S. Genomes of Diptera. Curr Opin Insect Sci. 2018 ;25:116-124.

Kaiser TS, Poehn B, Szkiba D, Preussner M, Sedlazeck FJ, Zrim A, et al.. The genomic basis of circadian and circalunar timing adaptations in a midge. Nature. 2016 ;540(7631):69-73.

Wang F, Jiang L, Chen Y, Haelterman NA, Bellen HJ, Chen R. FlyVar: a database for genetic variation in Drosophila melanogaster. Database (Oxford). 2015 ;2015.

Fuller ZL, Haynes GD, Zhu D, Batterton M, Chao H, Dugan S, et al.. Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura. G3 (Bethesda). 2014 ;4(12):2433-49.

Ellis LL, Huang W, Quinn AM, Ahuja A, Alfrejd B, Gomez FE, et al.. Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity. PLoS Genet. 2014 ;10(7):e1004522.

Chen Z-X, Sturgill D, Qu J, Jiang H, Park S, Boley N, et al.. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Genome Res. 2014 ;24(7):1209-23.

Huang W, Massouras A, Inoue Y, Peiffer J, Ràmia M, Tarone AM, et al.. Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines. Genome Res. 2014 ;24(7):1193-208.

Jusiak B, Karandikar UC, Kwak S-J, Wang F, Wang H, Chen R, et al.. Regulation of Drosophila eye development by the transcription factor Sine oculis. PLoS One. 2014 ;9(2):e89695.

Ober U, Ayroles JF, Stone EA, Richards S, Zhu D, Gibbs RA, et al.. Using whole-genome sequence data to predict quantitative trait phenotypes in Drosophila melanogaster. PLoS Genet. 2012 ;8(5):e1002685.

English AC, Richards S, Han Y, Wang M, Vee V, Qu J, et al.. Mind the gap: upgrading genomes with Pacific Biosciences RS long-read sequencing technology. PLoS One. 2012 ;7(11):e47768.