Title | Unique features of a global human ectoparasite identified through sequencing of the bed bug genome. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Benoit, JB, Adelman, ZN, Reinhardt, K, Dolan, A, Poelchau, M, Jennings, EC, Szuter, EM, Hagan, RW, Gujar, H, Shukla, JNath, Zhu, F, Mohan, M, Nelson, DR, Rosendale, AJ, Derst, C, Resnik, V, Wernig, S, Menegazzi, P, Wegener, C, Peschel, N, Hendershot, JM, Blenau, W, Predel, R, Johnston, PR, Ioannidis, P, Waterhouse, RM, Nauen, R, Schorn, C, Ott, M-C, Maiwald, F, J Johnston, S, Gondhalekar, AD, Scharf, ME, Peterson, BF, Raje, KR, Hottel, BA, Armisén, D, Crumière, AJean Johan, Refki, PNagui, Santos, MEmilia, Sghaier, E, Viala, S, Khila, A, Ahn, S-J, Childers, C, Lee, C-Y, Lin, H, Hughes, DST, Duncan, EJ, Murali, SC, Qu, J, Dugan, S, Lee, SL, Chao, H, Dinh, H, Han, Y, Doddapaneni, H, Worley, KC, Muzny, DM, Wheeler, D, Panfilio, KA, Jentzsch, IMVargas, Vargo, EL, Booth, W, Friedrich, M, Weirauch, MT, Anderson, MAE, Jones, JW, Mittapalli, O, Zhao, C, Zhou, J-J, Evans, JD, Attardo, GM, Robertson, HM, Zdobnov, EM, Ribeiro, JMC, Gibbs, RA, Werren, JH, Palli, SR, Schal, C, Richards, S |
Journal | Nat Commun |
Volume | 7 |
Pagination | 10165 |
Date Published | 2016 Feb 02 |
ISSN | 2041-1723 |
Keywords | Animals, Bedbugs, Ectoparasitic Infestations, Feeding Behavior, Gene Transfer, Horizontal, Genome, Host-Parasite Interactions, Humans, Insecticide Resistance, Insecticides, Sequence Analysis, DNA |
Abstract | The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite. |
DOI | 10.1038/ncomms10165 |
Alternate Journal | Nat Commun |
PubMed ID | 26836814 |
PubMed Central ID | PMC4740739 |
Grant List | GM070559-9 / GM / NIGMS NIH HHS / United States R01 GM070559 / GM / NIGMS NIH HHS / United States U54 HG003273 / HG / NHGRI NIH HHS / United States 260986 / ERC_ / European Research Council / International UL1 TR001427 / TR / NCATS NIH HHS / United States 616346 / ERC_ / European Research Council / International |
Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.
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