The trans-ancestral genomic architecture of glycemic traits.

TitleThe trans-ancestral genomic architecture of glycemic traits.
Publication TypeJournal Article
Year of Publication2021
AuthorsChen, J, Spracklen, CN, Marenne, G, Varshney, A, Corbin, LJ, Luan, J'an, Willems, SM, Wu, Y, Zhang, X, Horikoshi, M, Boutin, TS, Mägi, R, Waage, J, Li-Gao, R, Chan, KHang Katie, Yao, J, Anasanti, MD, Chu, AY, Claringbould, A, Heikkinen, J, Hong, J, Hottenga, J-J, Huo, S, Kaakinen, MA, Louie, T, Marz, W, Moreno-Macias, H, Ndungu, A, Nelson, SC, Nolte, IM, North, KE, Raulerson, CK, Ray, D, Rohde, R, Rybin, D, Schurmann, C, Sim, X, Southam, L, Stewart, ID, Wang, CA, Wang, Y, Wu, P, Zhang, W, Ahluwalia, TS, Appel, EVR, Bielak, LF, Brody, JA, Burtt, NP, Cabrera, CP, Cade, BE, Chai, JFang, Chai, X, Chang, L-C, Chen, C-H, Chen, BH, Chitrala, KNaidu, Chiu, Y-F, de Haan, HG, Delgado, GE, Demirkan, A, Duan, Q, Engmann, J, Fatumo, SA, Gayán, J, Giulianini, F, Gong, JHo, Gustafsson, S, Hai, Y, Hartwig, FP, He, J, Heianza, Y, Huang, T, Huerta-Chagoya, A, Hwang, MYeong, Jensen, RA, Kawaguchi, T, Kentistou, KA, Kim, YJin, Kleber, ME, Kooner, IK, Lai, S, Lange, LA, Langefeld, CD, Lauzon, M, Li, M, Ligthart, S, Liu, J, Loh, M, Long, J, Lyssenko, V, Mangino, M, Marzi, C, Montasser, ME, Nag, A, Nakatochi, M, Noce, D, Noordam, R, Pistis, G, Preuss, M, Raffield, L, Rasmussen-Torvik, LJ, Rich, SS, Robertson, NR, Rueedi, R, Ryan, K, Sanna, S, Saxena, R, Schraut, KE, Sennblad, B, Setoh, K, Smith, AV, Sparsø, T, Strawbridge, RJ, Takeuchi, F, Tan, J, Trompet, S, van den Akker, E, van der Most, PJ, Verweij, N, Vogel, M, Wang, H, Wang, C, Wang, N, Warren, HR, Wen, W, Wilsgaard, T, Wong, A, Wood, AR, Xie, T, Zafarmand, MHadi, Zhao, J-H, Zhao, W, Amin, N, Arzumanyan, Z, Astrup, A, Bakker, SJL, Baldassarre, D, Beekman, M, Bergman, RN, Bertoni, A, Blüher, M, Bonnycastle, LL, Bornstein, SR, Bowden, DW, Cai, Q, Campbell, A, Campbell, H, Chang, YCheng, de Geus, EJC, Dehghan, A, Du, S, Eiriksdottir, G, Farmaki, AEleni, Frånberg, M, Fuchsberger, C, Gao, Y, Gjesing, AP, Goel, A, Han, S, Hartman, CA, Herder, C, Hicks, AA, Hsieh, C-H, Hsueh, WA, Ichihara, S, Igase, M, M Ikram, A, W Johnson, C, Jørgensen, ME, Joshi, PK, Kalyani, RR, Kandeel, FR, Katsuya, T, Khor, CChuen, Kiess, W, Kolcic, I, Kuulasmaa, T, Kuusisto, J, Läll, K, Lam, K, Lawlor, DA, Lee, NR, Lemaitre, RN, Li, H, Lin, S-Y, Lindström, J, Linneberg, A, Liu, J, Lorenzo, C, Matsubara, T, Matsuda, F, Mingrone, G, Mooijaart, S, Moon, S, Nabika, T, Nadkarni, GN, Nadler, JL, Nelis, M, Neville, MJ, Norris, JM, Ohyagi, Y, Peters, A, Peyser, PA, Polasek, O, Qi, Q, Raven, D, Reilly, DF, Reiner, A, Rivideneira, F, Roll, K, Rudan, I, Sabanayagam, C, Sandow, K, Sattar, N, Schürmann, A, Shi, J, Stringham, HM, Taylor, KD, Teslovich, TM, Thuesen, B, Timmers, PRHJ, Tremoli, E, Tsai, MY, Uitterlinden, A, van Dam, RM, van Heemst, D, Vlieg, Avan Hylcka, Van Vliet-Ostaptchouk, JV, Vangipurapu, J, Vestergaard, H, Wang, T, van Dijk, KWillems, Zemunik, T, Abecasis, GR, Adair, LS, Aguilar-Salinas, CAlberto, Alarcón-Riquelme, ME, An, P, Aviles-Santa, L, Becker, DM, Beilin, LJ, Bergmann, S, Bisgaard, H, Black, C, Boehnke, M, Boerwinkle, E, Böhm, BO, Bønnelykke, K, Boomsma, DI, Bottinger, EP, Buchanan, TA, Canouil, M, Caulfield, MJ, Chambers, JC, Chasman, DI, Chen, Y-DIda, Cheng, C-Y, Collins, FS, Correa, A, Cucca, F, H de Silva, J, Dedoussis, G, Elmståhl, S, Evans, MK, Ferrannini, E, Ferrucci, L, Florez, JC, Franks, PW, Frayling, TM, Froguel, P, Gigante, B, Goodarzi, MO, Gordon-Larsen, P, Grallert, H, Grarup, N, Grimsgaard, S, Groop, L, Gudnason, V, Guo, X, Hamsten, A, Hansen, T, Hayward, C, Heckbert, SR, Horta, BL, Huang, W, Ingelsson, E, James, PS, Jarvelin, M-R, Jonas, JB, J Jukema, W, Kaleebu, P, Kaplan, R, Kardia, SLR, Kato, N, Keinanen-Kiukaanniemi, SM, Kim, B-J, Kivimaki, M, Koistinen, HA, Kooner, JS, Körner, A, Kovacs, P, Kuh, D, Kumari, M, Kutalik, Z, Laakso, M, Lakka, TA, Launer, LJ, Leander, K, Li, H, Lin, X, Lind, L, Lindgren, C, Liu, S, Loos, RJF, Magnusson, PKE, Mahajan, A, Metspalu, A, Mook-Kanamori, DO, Mori, TA, Munroe, PB, Njølstad, I, O'Connell, JR, Oldehinkel, AJ, Ong, KK, Padmanabhan, S, Palmer, CNA, Palmer, ND, Pedersen, O, Pennell, CE, Porteous, DJ, Pramstaller, PP, Province, MA, Psaty, BM, Qi, L, Raffel, LJ, Rauramaa, R, Redline, S, Ridker, PM, Rosendaal, FR, Saaristo, TE, Sandhu, M, Saramies, J, Schneiderman, N, Schwarz, P, Scott, LJ, Selvin, E, Sever, P, Shu, X-O, P Slagboom, E, Small, KS, Smith, BH, Snieder, H, Sofer, T, Sørensen, TIA, Spector, TD, Stanton, A, Steves, CJ, Stumvoll, M, Sun, L, Tabara, Y, E Tai, S, Timpson, NJ, Tonjes, A, Tuomilehto, J, Tusie, T, Uusitupa, M, van der Harst, P, van Duijn, C, Vitart, V, Vollenweider, P, Vrijkotte, TGM, Wagenknecht, LE, Walker, M, Wang, YX, Wareham, NJ, Watanabe, RM, Watkins, H, Wei, WB, Wickremasinghe, AR, Willemsen, G, Wilson, JF, Wong, T-Y, Wu, J-Y, Xiang, AH, Yanek, LR, Yengo, L, Yokota, M, Zeggini, E, Zheng, W, Zonderman, AB, Rotter, JI, Gloyn, AL, McCarthy, MI, Dupuis, J, Meigs, JB, Scott, RA, Prokopenko, I, Leong, A, Liu, C-T, Parker, SCJ, Mohlke, KL, Langenberg, C, Wheeler, E, Morris, AP, Barroso, I
Corporate AuthorsLifeLines Cohort Study, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
JournalNat Genet
Volume53
Issue6
Pagination840-860
Date Published2021 Jun
ISSN1546-1718
KeywordsAlleles, Blood Glucose, Epigenesis, Genetic, Gene Expression Profiling, Genome, Human, Genome-Wide Association Study, Glycated Hemoglobin, Humans, Multifactorial Inheritance, Physical Chromosome Mapping, Quantitative Trait Loci, Quantitative Trait, Heritable, White People
Abstract

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P 
DOI10.1038/s41588-021-00852-9
Alternate JournalNat Genet
PubMed ID34059833
PubMed Central IDPMC7610958
Grant ListD43 TW009077 / TW / FIC NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
U24 MH068457 / MH / NIMH NIH HHS / United States
RP-PG-0407-10371 / DH_ / Department of Health / United Kingdom
MC_UU_00006/1 / MRC_ / Medical Research Council / United Kingdom
K013351 / MRC_ / Medical Research Council / United Kingdom
G0601966 / MRC_ / Medical Research Council / United Kingdom
CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom
N01HC85080 / HL / NHLBI NIH HHS / United States
MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom
N01AG12109 / AG / NIA NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
R01 HL088119 / HL / NHLBI NIH HHS / United States
U01 DK085545 / DK / NIDDK NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
G952010 / MRC_ / Medical Research Council / United Kingdom
UM1 CA173640 / CA / NCI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom
R01 HL046380 / HL / NHLBI NIH HHS / United States
HHSN268201300005C / HL / NHLBI NIH HHS / United States
16/136/68 / DH_ / Department of Health / United Kingdom
06130 / WT_ / Wellcome Trust / United Kingdom
PG/11/63/29011 / BHF_ / British Heart Foundation / United Kingdom
P01 HL136275 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
T32 GM067553 / GM / NIGMS NIH HHS / United States
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MR/M013138/1 / MRC_ / Medical Research Council / United Kingdom
UL1 TR001881 / TR / NCATS NIH HHS / United States
G0901213 / MRC_ / Medical Research Council / United Kingdom
RG/16/11/32334 / BHF_ / British Heart Foundation / United Kingdom
104036/Z/14/Z / WT_ / Wellcome Trust / United Kingdom
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SP/04/002 / BHF_ / British Heart Foundation / United Kingdom
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