Title | Research ethics and the challenge of whole-genome sequencing. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | McGuire, AL, Caulfield, T, Cho, MK |
Journal | Nat Rev Genet |
Volume | 9 |
Issue | 2 |
Pagination | 152-6 |
Date Published | 2008 Feb |
ISSN | 1471-0064 |
Keywords | Ethics, Research, Family, Genome, Human, Health Planning Guidelines, Humans, Molecular Sequence Data, Public Policy, Publishing, Research, Research Subjects, Sequence Analysis, DNA, Third-Party Consent |
Abstract | The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing. |
DOI | 10.1038/nrg2302 |
Alternate Journal | Nat Rev Genet |
PubMed ID | 18087293 |
PubMed Central ID | PMC2225443 |
Grant List | 5P50HG003389 / HG / NHGRI NIH HHS / United States R01 HG004333 / HG / NHGRI NIH HHS / United States P50 HG003389-04 / HG / NHGRI NIH HHS / United States R01HG004333 / HG / NHGRI NIH HHS / United States P50 HG003389 / HG / NHGRI NIH HHS / United States |
Research ethics and the challenge of whole-genome sequencing.
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