Title | Multiple genome alignment in the telomere-to-telomere assembly era. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Kille, B, Balaji, A, Sedlazeck, FJ, Nute, M, Treangen, TJ |
Journal | Genome Biol |
Volume | 23 |
Issue | 1 |
Pagination | 182 |
Date Published | 2022 Aug 29 |
ISSN | 1474-760X |
Keywords | Genome, Human, Genomics, Humans, Nucleotides, Telomere |
Abstract | With the arrival of telomere-to-telomere (T2T) assemblies of the human genome comes the computational challenge of efficiently and accurately constructing multiple genome alignments at an unprecedented scale. By identifying nucleotides across genomes which share a common ancestor, multiple genome alignments commonly serve as the bedrock for comparative genomics studies. In this review, we provide an overview of the algorithmic template that most multiple genome alignment methods follow. We also discuss prospective areas of improvement of multiple genome alignment for keeping up with continuously arriving high-quality T2T assembled genomes and for unlocking clinically-relevant insights. |
DOI | 10.1186/s13059-022-02735-6 |
Alternate Journal | Genome Biol |
PubMed ID | 36038949 |
PubMed Central ID | PMC9421119 |
Grant List | P01 AI152999 / AI / NIAID NIH HHS / United States T15 LM007093 / LM / NLM NIH HHS / United States |
Multiple genome alignment in the telomere-to-telomere assembly era.
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