Title | Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Justice, AE, Chittoor, G, Gondalia, R, Melton, PE, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, L Cupples, A, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, TA, Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AGreen, North, KE |
Journal | Epigenomics |
Volume | 12 |
Issue | 17 |
Pagination | 1483-1499 |
Date Published | 2020 Sep |
ISSN | 1750-192X |
Keywords | Adiposity, Cohort Studies, CpG Islands, Disease Susceptibility, DNA Methylation, Endocrine System, Epigenesis, Genetic, Epigenomics, Genome-Wide Association Study, Humans, Immune System, Obesity |
Abstract | We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near , , and that had not previously been associated with obesity-related traits. |
DOI | 10.2217/epi-2019-0276 |
Alternate Journal | Epigenomics |
PubMed ID | 32901515 |
PubMed Central ID | PMC7923253 |
Grant List | RC2 HL102419 / HL / NHLBI NIH HHS / United States K99 HL130580 / HL / NHLBI NIH HHS / United States R01 HL143885 / HL / NHLBI NIH HHS / United States HHSN268201600002C / HL / NHLBI NIH HHS / United States R01 ES020836 / ES / NIEHS NIH HHS / United States R01 NS087541 / NS / NINDS NIH HHS / United States R00 HL130580 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States HHSN268201600004C / HL / NHLBI NIH HHS / United States HHSN268201600001C / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States 75N92019D00031 / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States HHSN268201600018C / HL / NHLBI NIH HHS / United States R01 HG009974 / HG / NHGRI NIH HHS / United States HHSN268201700004C / HB / NHLBI NIH HHS / United States HHSN268201600003C / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700005C / HL / NHLBI NIH HHS / United States HHSN268201700001C / HL / NHLBI NIH HHS / United States HHSN268201700002C / HB / NHLBI NIH HHS / United States HHSN268201700003C / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States R01 HG010297 / HG / NHGRI NIH HHS / United States |
Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
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