Title | Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Christian, MKA, Samms-Vaughan, M, Lee, MJ, Bressler, J, Hessabi, M, Grove, ML, Shakespeare-Pellington, S, Desai, CCoore, Reece, J-A, Loveland, KA, Boerwinkle, E, Rahbar, MH |
Journal | J Autism Dev Disord |
Volume | 48 |
Issue | 8 |
Pagination | 2766-2778 |
Date Published | 2018 Aug |
ISSN | 1573-3432 |
Keywords | Adult, Autism Spectrum Disorder, Child, Communicable Diseases, Female, Humans, Jamaica, Male, Maternal Exposure, Pesticides, Pregnancy, Volatile Organic Compounds |
Abstract | Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with poorly understood etiology. Many maternal exposures during pregnancy and breastfeeding potentially interfere with neurodevelopment. Using data from two age- and sex-matched case-control studies in Jamaica (n = 298 pairs), results of conditional logistic regression analyses suggest that maternal exposures to fever or infection (matched odds ratio (MOR) = 3.12, 95% CI 1.74-5.60), physical trauma (MOR 2.02, 95% CI 1.01-4.05), and oil-based paints (MOR 1.99, 95% CI 1.14-3.46) may be associated with ASD. Additionally, maternal exposure to oil-based paints may modify the relationship between maternal exposure to pesticides and ASD, which deepens our understanding of the association between pesticides and ASD. |
DOI | 10.1007/s10803-018-3537-6 |
Alternate Journal | J Autism Dev Disord |
PubMed ID | 29549549 |
PubMed Central ID | PMC6041149 |
Grant List | R01 ES022165 / ES / NIEHS NIH HHS / United States R21HD057808 / NH / NIH HHS / United States R21 HD057808 / HD / NICHD NIH HHS / United States UL1 TR003167 / TR / NCATS NIH HHS / United States R01ES022165 / NH / NIH HHS / United States UL1 RR024148 / RR / NCRR NIH HHS / United States UL1 TR000371 / TR / NCATS NIH HHS / United States |
Maternal Exposures Associated with Autism Spectrum Disorder in Jamaican Children.
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