Title | A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.). |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Sherwood, RJ, Duren, DL, Havill, LM, Rogers, J, Cox, LA, Towne, B, Mahaney, MC |
Journal | Genetics |
Volume | 180 |
Issue | 1 |
Pagination | 619-28 |
Date Published | 2008 Sep |
ISSN | 0016-6731 |
Keywords | Animals, Anthropometry, Female, Genetic Linkage, Genetic Variation, Genome, Humans, Likelihood Functions, Male, Models, Biological, Models, Genetic, Papio hamadryas, Quantitative Trait Loci, Skull, Species Specificity |
Abstract | Numerous studies have detected significant contributions of genes to variation in development, size, and shape of craniofacial traits in a number of vertebrate taxa. This study examines 43 quantitative traits derived from lateral cephalographs of 830 baboons (Papio hamadryas) from the pedigreed population housed at the Southwest National Primate Research Center. Quantitative genetic analyses were conducted using the SOLAR analytic platform, a maximum-likelihood variance components method that incorporates all familial information for parameter estimation. Heritability estimates were significant and of moderate to high magnitude for all craniofacial traits. Additionally, 14 significant quantitative trait loci (QTL) were identified for 12 traits from the three developmental components (basicranium, splanchnocranium, and neurocranium) of the craniofacial complex. These QTL were found on baboon chromosomes (and human orthologs) PHA1 (HSA1), PHA 2 (HSA3), PHA4 (HSA6), PHA11 (HSA12), PHA13 (HSA2), PHA16 (HSA17), and PHA17 (HSA13) (PHA, P. hamadryas; HSA, Homo sapiens). This study of the genetic architecture of the craniofacial complex in baboons provides the groundwork needed to establish the baboon as an animal model for the study of genetic and nongenetic influences on craniofacial variation. |
DOI | 10.1534/genetics.108.090407 |
Alternate Journal | Genetics |
PubMed ID | 18757921 |
PubMed Central ID | PMC2535711 |
Grant List | R01 DE016692 / DE / NIDCR NIH HHS / United States C06 RR013556 / RR / NCRR NIH HHS / United States P01 HL028972 / HL / NHLBI NIH HHS / United States P51 RR13986 / RR / NCRR NIH HHS / United States R01 MH059490 / MH / NIMH NIH HHS / United States R37 MH059490 / MH / NIMH NIH HHS / United States P01HL28972 / HL / NHLBI NIH HHS / United States DE016692 / DE / NIDCR NIH HHS / United States MH059490 / MH / NIMH NIH HHS / United States C06 RR017515 / RR / NCRR NIH HHS / United States R21 DE016408 / DE / NIDCR NIH HHS / United States C06 RR15456 / RR / NCRR NIH HHS / United States C06 RR015456 / RR / NCRR NIH HHS / United States DE016408 / DE / NIDCR NIH HHS / United States P51 RR013986 / RR / NCRR NIH HHS / United States |
A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.).
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