Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment.

TitleGenetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment.
Publication TypeJournal Article
Year of Publication2023
AuthorsGranot-Hershkovitz, E, Spitzer, B, Yang, Y, Tarraf, W, Yu, B, Boerwinkle, E, Fornage, M, Mosley, TH, DeCarli, C, Kristal, BS, Gonzalez, HM, Sofer, T
JournalTransl Psychiatry
Volume13
Issue1
Pagination140
Date Published2023 Apr 29
ISSN2158-3188
KeywordsAging, Genetic Loci, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide
Abstract

We studied the genetic associations of a previously developed Metabolomic Risk Score (MRS) for Mild Cognitive Impairment (MCI) and beta-aminoisobutyric acid metabolite (BAIBA)-the metabolite highlighted by results from a genome-wide association study (GWAS) of the MCI-MRS, and assessed their association with MCI in datasets of diverse race/ethnicities. We first performed a GWAS for the MCI-MRS and BAIBA, in Hispanic/Latino adults (n = 3890) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We identified ten independent genome-wide significant (p value

DOI10.1038/s41398-023-02437-y
Alternate JournalTransl Psychiatry
PubMed ID37120436
PubMed Central IDPMC10148805
Grant ListR01 AG048642 / AG / NIA NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
N01HC65233 / HL / NHLBI NIH HHS / United States
R21 AG070644 / AG / NIA NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
P30 AG059299 / AG / NIA NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
N01HC65236 / HL / NHLBI NIH HHS / United States
P30 AG062429 / AG / NIA NIH HHS / United States
RF1 AG054548 / AG / NIA NIH HHS / United States
RF1 AG061022 / AG / NIA NIH HHS / United States
N01HC65237 / HL / NHLBI NIH HHS / United States
R21 AG056952 / AG / NIA NIH HHS / United States
N01HC65234 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
N01HC65235 / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States

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