Association Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk.

TitleAssociation Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk.
Publication TypeJournal Article
Year of Publication2023
AuthorsLiu, X, Sun, X, Zhang, Y, Jiang, W, Lai, M, Wiggins, KL, Raffield, LM, Bielak, LF, Zhao, W, Pitsillides, A, Haessler, J, Zheng, Y, Blackwell, TW, Yao, J, Guo, X, Qian, Y, Thyagarajan, B, Pankratz, N, Rich, SS, Taylor, KD, Peyser, PA, Heckbert, SR, Seshadri, S, Boerwinkle, E, Grove, ML, Larson, NB, Smith, JA, Vasan, RS, Fitzpatrick, AL, Fornage, M, Ding, J, Carson, AP, Abecasis, G, Dupuis, J, Reiner, A, Kooperberg, C, Hou, L, Psaty, BM, Wilson, JG, Levy, D, Rotter, JI, Bis, JC, Satizabal, CL, Arking, DE, Liu, C
Corporate AuthorsTOPMed mtDNA Working Group in NHLBI Trans‐Omics for Precision Medicine (TOPMed) Consortium
JournalJ Am Heart Assoc
Volume12
Issue20
Paginatione029090
Date Published2023 Oct 17
ISSN2047-9980
KeywordsCardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Coronary Disease, Cross-Sectional Studies, Diabetes Mellitus, DNA Copy Number Variations, DNA, Mitochondrial, Humans, Hypertension, Obesity, Risk Factors
Abstract

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia).

DOI10.1161/JAHA.122.029090
Alternate JournalJ Am Heart Assoc
PubMed ID37804200
PubMed Central IDPMC10757530
Grant ListR01 HL092577 / HL / NHLBI NIH HHS / United States
75N92021D00006 / HL / NHLBI NIH HHS / United States
N01 HC095166 / HC / NHLBI NIH HHS / United States
N01 HC095160 / HC / NHLBI NIH HHS / United States
N01 HC095163 / HC / NHLBI NIH HHS / United States
HHSN268201100037C / HL / NHLBI NIH HHS / United States
75N92020D00002 / HL / NHLBI NIH HHS / United States
HHSN268201500003C / HL / NHLBI NIH HHS / United States
75N92020D00005 / HL / NHLBI NIH HHS / United States
75N92022D00002 / HL / NHLBI NIH HHS / United States
U54 HG003067 / HG / NHGRI NIH HHS / United States
N01 HC095168 / HC / NHLBI NIH HHS / United States
HHSN268201000031C / HL / NHLBI NIH HHS / United States
N01 HC085079 / HC / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
HHSN268201800004I / HL / NHLBI NIH HHS / United States
75N92020D00001 / HL / NHLBI NIH HHS / United States
HHSN268201500001C / HL / NHLBI NIH HHS / United States
75N92019D00031 / HL / NHLBI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
N01 HC085082 / HC / NHLBI NIH HHS / United States
HHSN268201800014I / HB / NHLBI NIH HHS / United States
HHSN268201500014C / HL / NHLBI NIH HHS / United States
75N92021D00004 / WH / WHI NIH HHS / United States
N01 HC095162 / HC / NHLBI NIH HHS / United States
N01 HC085086 / HC / NHLBI NIH HHS / United States
U54 HG003273 / HG / NHGRI NIH HHS / United States
UL1 TR001420 / TR / NCATS NIH HHS / United States
N01 HC095165 / HC / NHLBI NIH HHS / United States
HHSN268201800014C / HL / NHLBI NIH HHS / United States
75N92021D00005 / WH / WHI NIH HHS / United States
75N92020D00003 / HL / NHLBI NIH HHS / United States
N01 HC085081 / HC / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
HHSN268201800012I / HB / NHLBI NIH HHS / United States
75N92021D00001 / HL / NHLBI NIH HHS / United States
HHSN268201800007I / HL / NHLBI NIH HHS / United States
HHSN268201800003I / HL / NHLBI NIH HHS / United States
75N92022D00003 / HL / NHLBI NIH HHS / United States
N01 HC095169 / HC / NHLBI NIH HHS / United States
R01 AG059727 / AG / NIA NIH HHS / United States
75N92021D00003 / WH / WHI NIH HHS / United States
HHSN268201200036C / HL / NHLBI NIH HHS / United States
HHSN268201800001C / HL / NHLBI NIH HHS / United States
HHSN268201800013I / MD / NIMHD NIH HHS / United States
75N92022D00004 / HL / NHLBI NIH HHS / United States
N01 HC095159 / HC / NHLBI NIH HHS / United States
HHSN268201600033C / ES / NIEHS NIH HHS / United States
N01 HC095161 / HC / NHLBI NIH HHS / United States
HHSN268201500001I / HL / NHLBI NIH HHS / United States
N01 HC085083 / HC / NHLBI NIH HHS / United States
75N92020D00004 / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
HHSN268201800011I / HB / NHLBI NIH HHS / United States
75N92020D00007 / HL / NHLBI NIH HHS / United States
HHSN268201500003I / HL / NHLBI NIH HHS / United States
KL2 TR002490 / TR / NCATS NIH HHS / United States
U01 HL120393 / HL / NHLBI NIH HHS / United States
HHSN268201800015I / HB / NHLBI NIH HHS / United States
UL1 TR001079 / TR / NCATS NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
HHSN268201800010I / HB / NHLBI NIH HHS / United States
HHSN268200800007C / HL / NHLBI NIH HHS / United States
75N92020D00006 / HL / NHLBI NIH HHS / United States
N01 HC085080 / HC / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
75N92022D00005 / HL / NHLBI NIH HHS / United States
N01 HC095167 / HC / NHLBI NIH HHS / United States
HHSN268201800005I / HL / NHLBI NIH HHS / United States
HHSN268201500015C / HL / NHLBI NIH HHS / United States
75N92022D00001 / HL / NHLBI NIH HHS / United States
HHSN268201800006I / HL / NHLBI NIH HHS / United States
N01 HC095164 / HC / NHLBI NIH HHS / United States
R01 HL055673 / HL / NHLBI NIH HHS / United States
R01 HL117626 / HL / NHLBI NIH HHS / United States
75N92021D00002 / HL / NHLBI NIH HHS / United States

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