Title | ADD1 460W allele associated with cardiovascular disease in hypertensive individuals. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Morrison, AC, Bray, MS, Folsom, AR, Boerwinkle, E |
Journal | Hypertension |
Volume | 39 |
Issue | 6 |
Pagination | 1053-7 |
Date Published | 2002 Jun |
ISSN | 1524-4563 |
Keywords | Alleles, Arterial Occlusive Diseases, Calmodulin-Binding Proteins, Cardiovascular Diseases, Case-Control Studies, Coronary Disease, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Heterotrimeric GTP-Binding Proteins, Humans, Hypertension, Incidence, Male, Middle Aged, Polymorphism, Single Nucleotide, Prevalence, White People |
Abstract | High blood pressure is a predictor of cardiovascular disease. Hence, genes contributing to essential hypertension may play a role in the etiology of cardiovascular disease. For this reason, we examined the association between the alpha-adducin (ADD1) G460W and G-protein beta3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study. PAD prevalence was defined by an ankle-brachial index, ie, the ratio of ankle systolic blood pressure to brachial artery systolic blood pressure, of |
DOI | 10.1161/01.hyp.0000019128.94483.3a |
Alternate Journal | Hypertension |
PubMed ID | 12052841 |
Grant List | N01-HC-55015 / HC / NHLBI NIH HHS / United States N01-HC-55016 / HC / NHLBI NIH HHS / United States N01-HC-55018 / HC / NHLBI NIH HHS / United States N01-HC-55019 / HC / NHLBI NIH HHS / United States N01-HC-55020 / HC / NHLBI NIH HHS / United States N01-HC-55021 / HC / NHLBI NIH HHS / United States N01-HC-55022 / HC / NHLBI NIH HHS / United States |
ADD1 460W allele associated with cardiovascular disease in hypertensive individuals.
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