Title | A comprehensive transcriptional map of primate brain development. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Bakken, TE, Miller, JA, Ding, S-L, Sunkin, SM, Smith, KA, Ng, L, Szafer, A, Dalley, RA, Royall, JJ, Lemon, T, Shapouri, S, Aiona, K, Arnold, J, Bennett, JL, Bertagnolli, D, Bickley, K, Boe, A, Brouner, K, Butler, S, Byrnes, E, Caldejon, S, Carey, A, Cate, S, Chapin, M, Chen, J, Dee, N, Desta, T, Dolbeare, TA, Dotson, N, Ebbert, A, Fulfs, E, Gee, G, Gilbert, TL, Goldy, J, Gourley, L, Gregor, B, Gu, G, Hall, J, Haradon, Z, Haynor, DR, Hejazinia, N, Hoerder-Suabedissen, A, Howard, R, Jochim, J, Kinnunen, M, Kriedberg, A, Kuan, CL, Lau, C, Lee, C-K, Lee, F, Luong, L, Mastan, N, May, R, Melchor, J, Mosqueda, N, Mott, E, Ngo, K, Nyhus, J, Oldre, A, Olson, E, Parente, J, Parker, PD, Parry, S, Pendergraft, J, Potekhina, L, Reding, M, Riley, ZL, Roberts, T, Rogers, B, Roll, K, Rosen, D, Sandman, D, Sarreal, M, Shapovalova, N, Shi, S, Sjoquist, N, Sodt, AJ, Townsend, R, Velasquez, L, Wagley, U, Wakeman, WB, White, C, Bennett, C, Wu, J, Young, R, Youngstrom, BL, Wohnoutka, P, Gibbs, RA, Rogers, J, Hohmann, JG, Hawrylycz, MJ, Hevner, RF, Molnár, Z, Phillips, JW, Dang, C, Jones, AR, Amaral, DG, Bernard, A, Lein, ES |
Journal | Nature |
Volume | 535 |
Issue | 7612 |
Pagination | 367-75 |
Date Published | 2016 Jul 21 |
ISSN | 1476-4687 |
Keywords | Aging, Animals, Autism Spectrum Disorder, Brain, Cell Adhesion, Conserved Sequence, Female, Humans, Intellectual Disability, Macaca mulatta, Male, Microcephaly, Neocortex, Neurodevelopmental Disorders, Neurogenesis, Risk Factors, Schizophrenia, Spatio-Temporal Analysis, Species Specificity, Transcription, Genetic, Transcriptome |
Abstract | The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons. Cortical layers and areas acquire adult-like molecular profiles surprisingly late in postnatal development. Disparate cell populations exhibit distinct developmental timing of gene expression, but also unexpected synchrony of processes underlying neural circuit construction including cell projection and adhesion. Candidate risk genes for neurodevelopmental disorders including primary microcephaly, autism spectrum disorder, intellectual disability, and schizophrenia show disease-specific spatiotemporal enrichment within developing neocortex. Human developmental expression trajectories are more similar to monkey than rodent, although approximately 9% of genes show human-specific regulation with evidence for prolonged maturation or neoteny compared to monkey. |
DOI | 10.1038/nature18637 |
Alternate Journal | Nature |
PubMed ID | 27409810 |
PubMed Central ID | PMC5325728 |
Grant List | HHSN271200800047C / MH / NIMH NIH HHS / United States MR/N026039/1 / MRC_ / Medical Research Council / United Kingdom RR00169 / RR / NCRR NIH HHS / United States P51 RR000169 / RR / NCRR NIH HHS / United States G0500180 / MRC_ / Medical Research Council / United Kingdom G0700377 / MRC_ / Medical Research Council / United Kingdom |
A comprehensive transcriptional map of primate brain development.
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