Title | Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Wang, M, Futamura, M, Wang, Y, You, M |
Journal | Oncogene |
Volume | 24 |
Issue | 11 |
Pagination | 1958-63 |
Date Published | 2005 Mar 10 |
ISSN | 0950-9232 |
Keywords | Adenoma, Amino Acid Sequence, Animals, Base Sequence, DNA Primers, Exons, Genetic Predisposition to Disease, Lung Neoplasms, Mice, Molecular Sequence Data, Sequence Alignment, Sequence Homology, Amino Acid, Tumor Suppressor Proteins |
Abstract | Pas1 candidate 1 (Pas1c1) gene (also named Lmna-rs1) was found to encode two alternatively spliced mRNA transcripts (i.e. Pas1c1-Va and Pas1c1-Vb). In this study, we identified three additional mRNA transcripts encoded by the Pas1c1 gene, which were designated as Pas1c1-Vc, Pas1c1-Vd, and Pas1c1-Ve, respectively. Similar to Pas1c1-Vb, the newly identified transcripts were only expressed in mouse lung tissues from strains carrying the Pas1-susceptible (Pas1/s) allele. Pas1c1 transcripts were also detected in heart, testis, or brain but not in liver, spleen, or kidney. An 11-nucleotide polymorphism was found within the 3'-acceptor splice site of exon 8, which cosegregates with mouse strain Pas1 alleles and may underlie the strain-specific exon 8 skipping. We also found that ectopic expression of the Pas1c1-Va and Pas1c1-Vb in COS7 and NIH3T3 cells exhibited distinct intracellular distributions. These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation. |
DOI | 10.1038/sj.onc.1208295 |
Alternate Journal | Oncogene |
PubMed ID | 15688036 |
Grant List | R01CA58554 / CA / NCI NIH HHS / United States R01ES012063 / ES / NIEHS NIH HHS / United States |
Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.
Similar Publications
NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy. Genome Med. 2024;16(1):53. | .
Core planar cell polarity genes and in predisposition to congenital vertebral malformations. Proc Natl Acad Sci U S A. 2024;121(18):e2310283121. | .
The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression. Cell. 2024;187(5):1223-1237.e16. | .